Diseases have undeniable effects on Health-Related Quality of Life (HRQoL) . Chronic diseases, in
particular , limit the productive potentials and HRQoL of individuals. EQ-5D is a very popular generic
instrument, which can be used to estimate HRQoL scores in any diseases. The current study investigates
mean HRQoL scores in certain chronic diseases and examines the relationship between utility scores and
chronic diseases in Iran.


This cross-sectional study was carried out among the general adult population of Tehran. 3060
individuals were chosen by a strati¦ed probability sampling method. The EQ-5D-5L questionnaire was
applied. The utility scores were estimated using the Iranian crosswalk-based value set. The effect of
chronic diseases on the HRQoL scores was derived by the Ordinary Least Squares (OLS) method. Data
was analyzed using Stata version 13 software.


The mean ± standard deviation utility and EQ-V AS scores were 0.86 ±0.14 and 77.50 ±16.14 in the
participants without any chronic conditions. The scores were 0.69 ±0.17 and 61.61 ±20.39 in the
participants with chronic conditions. The highest and lowest mean utility scores were related to thyroid
disease (0.70) and Stroke (0.54) , respectively. Common chronic conditions had significant negative
effects on the HRQoL scores. Stroke (0.204) and cancer (0.177) caused the most reduction in the EQ-5D-5L utility scores. Lumbar disc hernia, digestive diseases, osteoarthritis, breathing problems, and
anxiety/nerves cause 0.133, 0.109, 0.108, 0.087, and 0.078 reductions, respectively, in the EQ-5D-5L utility


This study provides insight into some common chronic conditions and their effects on the HRQoL.
Policymakers and planners should pay attention to the effects of chronic conditions especially high
prevalence one. They should adopt effective interventions to control this issue and increase health. The
results of this study can also be beneficial in economic evaluation studies.


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