Abstract Background and purpose: Identification of risk in hospital waste management have a major role in reducing the cost of surplus and preventing the spread of diseases. In this quantitative analysis, we aimed at determining waste components, evaluating hospital waste management, and prioritizing the risks in Sari Fatemeh Zahra Hospital. Materials and methods: We performed a descriptive-cross-sectional study in 2015. Tchobanoglous method was used for quantitative-physical analysis of the waste. The individualized rapid assessment tool was applied to evaluate waste management. Preliminary Hazard Analysis and failure mode and effect analysis models were used to identify and prioritize the risks. Results: Total waste production, general waste, infectious wastes, and sharp objects were 1011.54, 600.45, 384.94, and 26.15 kg/day, respectively. Plastics, organic materials, and textiles constituted the highest amount of waste products. According to the individualized rapid assessment tool, the score obtained by the hospital was 82.15% indicating an excellent waste management. In preliminary hazard analysis, failure mode, and effect analysis models, 23 errors were observed, of which 9 had a priority number greater than 100. Conclusion: The models studied showed that mixing the sharp waste material with other garbage, disposal of non-infectious and semi-household waste in infectious bins and vice versa are of high risk and need corrective measures. Keywords: hospital waste management,quantitative analysis, risk assessment,preliminary hazard analysis, Hazard Analysis and Failure mode.