e-Health is critically important to build strong health systems, and accelerate the achievement of sustainable development goals, particularly universal health coverage. To support and strengthen the health system, the e-Health architecture needs to be formulated and established prior to the implementation and development of any national e-Health applications and services. The aim of this study is to design and validate a standard questionnaire to assess the current status of national e-Health architecture (NEHA) components.

Methods and analysis:

This study will use a mixed-methods design consisting of four phases: (1) item generation through review of evidences and experts’ opinions, (2) face and content validity of the questionnaire, (3) determination of a range of possible scenarios for each item included in the questionnaire and (4) evaluation of reliability. This questionnaire is expected to generate critical and important information about the status of NEHA components that will be useful for monitoring, formulating, developing, implementing and evaluating NEHA. Our paper will contribute, we envisage, to establishment of a socio-technical basis on which governments and other relevant sectors can compare the policy interventions that boost the availability and utilization of e-Health services within their settings.

Ethics and dissemination:

The Ethics Committee for Research at the Tehran University of Medical Sciences approved the study protocol. We will obtain informed consent from each participant and collect data anonymously to maintain confidentiality. The translation of the findings into future policy planning will include the production of a series of peer-reviewed articles, presentation of the findings at relevant e-Health conferences and preparation of policy reports to the international organizations aiming to strengthen national capacity for better-informed e-Health architecture.

*This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial.


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