In every Health Transformation Plan, operational challenges and the distance from the primary goals need to be identified. So, the main purpose of this study was obtaining effects and challenges of plan observed by healthcare providers. Participants of this conventional quali¬tative method of content analysis study were 45 supervisors and employees who affiliated to Tehran University of Medical Sciences. The challenges differed according to the study places (Community Health Centers, Health Posts and Health Homes) in Work contracts, Integrated Health System, Financial Management, Intermediary companies, Quality, Supervision, Payments, Locations and Family Physician Plan. To effectively implement a health plan and achieve its goals, the issues and challenges of the public health providers must be considered and addressed.